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KMID : 0848120120370030121
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International Journal of Oral Biology
2012 Volume.37 No. 3 p.121 ~ p.129
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Glia Dose not Participate in Antinociceptive Effects of Gabapentin
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Ahn Dong-K.
Yang Kui-Ye
Kim Hak-K
Jin Myoung-Uk
Ju Jin-Sook
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Abstract
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Previous clinical studies have demonstrated that gabapentin,a drug that binds to the voltage-gated calciumchannel α2δ1 subunit proteins, is effective in the managementof neuropathic pain, but there is limited evidencethat addresses the participation of glial cells in the antiallodyniceffects of this drug. The present study investigatedthe participation of glial cells in the anti-nociceptiveeffects of gabapentin in rats with trigeminal neuropathicpain produced by mal-positioned dental implants. Underanesthesia, the left mandibular second molar was extractedand replaced by a miniature dental implant to induce injuryto the inferior alveolar nerve. Mal-positioned dental implantssignificantly decreased the air-puff thresholds bothipsilateral and contralateral to the injury site. Gabapentinwas administered intracisternally beginning on postoperativeday (POD) 1 or on POD 7 for three days. Early orlate treatment with 0.3, 3, or 30 μg of gabapentin producedsignificant anti-allodynic effect in the rats with mal-positioneddental implants. On POD 9, in the mal-positioneddental implants group, OX-42, a microglia marker, andGFAP, an astrocyte marker, were found to be up-regulatedin the medullary dorsal horn, compared with the naivegroup. However, the intracisternal administration of gabapentin(30 μg) failed to reduce the number of activatedmicroglia or astrocytes in the medullary dorsal horn. Thesefindings suggest that gabapentin produces significant antinociceptiveeffects, which are not mediated by the inhibitionof glial cell function in the medullary dorsal horn, ina rat model of trigeminal neuropathic pain.
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KEYWORD
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dental implant, gabapentin, glia, inferior alveolar nerve, neuropathic pain
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